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Diazepam is N-demethylated by CYP3A4 and 2C19 towards the active metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 into the Energetic metabolite temazepam. N-desmethyldiazepam and temazepam are the two more metabolized to oxazepam. Temazepam and oxazepam are largely eradicated by glucuronidation.Other: modifications in salivation, whi